Enclomiphene Direct
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Compounded, not FDA-approved

Enclomiphene raised testosterone in every major trial. The ads stop there. The record does not.

This molecule went the whole distance: phase III trials against testosterone gel, an FDA filing, an advisory committee date. Then FDA cancelled the vote and issued a complete response letter, Europe refused it over missing symptom evidence and clot risk, and the company sold for 67 cents a share. Today the same trials sell it as a compounded product. We publish the trials with their numbers, the two regulatory endings, the isomer pharmacology that makes it genuinely interesting, and the approved 1967 sibling it competes with.

Start provider reviewBrowse the guides
  • 48fetch-verified sources: 28 peer-reviewed, 20 government or registry
  • 21studies in the graded evidence table, species labeled on every row
  • 9primary regulatory documents quoted: FDA, EMA, Federal Register and SEC filings
  • 19cited rows across the vs-clomiphene and vs-TRT comparison tables

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Key facts

  • StatusCompounded, not FDA-approved
  • Half lifeAbout 7 hours for enclomiphene (serum half-life as cited in the published phase II report) hsource
  • Isomer contrastZuclomiphene half-life is measured in days vs hours for enclomiphene (FDA PCAC meeting material); the Clomid label reports detectable zuclomiphene beyond a month and label residue in feces 6 weeks after dosingsource
  • TmaxEnclomiphene tmax about 3 h vs zuclomiphene about 7 h after a single oral clomiphene dose hsource
  • Exposure asymmetrySingle 50 mg clomiphene dose: zuclomiphene AUC 1289 vs enclomiphene AUC 65 ng/mL x h; on chronic clomiphene 25 mg daily the serum zu:en ratio is about 20:1source
  • WashoutEnclomiphene washes out within days (5 half-lives is about 35 hours); zuclomiphene remained urine-detectable 121 to more than 261 days after 30 days of clomiphenesource
  • AbsorptionReadily absorbed orally in humans; excreted principally in feces (label pharmacokinetics for the mixed-isomer drug)source
  • MetabolismCYP2D6 is the primary enzyme metabolizing enclomiphene in vitro; quinidine abolished metabolism in human liver microsomessource
  • RouteOral capsules (12.5 mg and 25 mg were the strengths in the FDA-filed NDA); compounded products also sold as capsules and sublingual formssource
  • ClassSelective estrogen receptor modulator (SERM); trans-isomer of clomipheneReview or guidelinesource
  • Approved relativeClomiphene citrate (Clomid, NDA 016131, approved 1967, generics available), a 30-50% zuclomiphene mixtureRegulatory recordsource
  • FormOral (capsules; 12.5 mg and 25 mg in the filed NDA)Regulatory recordsource
  • US regulatory endingFDA Complete Response Letter, December 1, 2015 (NDA 207959 not approvable in its filed form)Regulatory recordsource
  • EU regulatory endingEMA CHMP refusal of EnCyzix (enclomifene), January 25, 2018Regulatory recordsource
  • Serum half-lifeAbout 7 hours (vs a zuclomiphene half-life measured in days)Human PKsource
  • Doses studied6.25, 12.5 and 25 mg daily in the Androxal programHuman trialsource
  • MoleculeC26H28ClNO, MW 406.0, CAS 15690-57-0 (PubChem CID 1548953)Chemical referencesource
  • Development codesAndroxal (Repros Therapeutics); earlier codes RMI 16,289 and ICI 46476; EU trade name EnCyzixChemical referencesource

Read the full Enclomiphene monograph

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Everything on enclomiphene, organized the way you research it.

Evidence20 articlesSafety15 articlesSourcing12 articlesDosing10 articlesComparisons8 articles

Free Enclomiphene tools

Practical calculators and references, each scoped and sourced.

Review-gated tools: these tools are excluded from search and AI citation and must not be used as hormone, fertility, monitoring, or treatment instruction.

T-01Enclomiphene study-dose explorerEvery dose regimen actually used in the enclomiphene clinical program, selectable by trial, with the population enrolled, the comparator, and the testosterone, LH, FSH and sperm outcomes each arm produced. It answers 'what have humans actually been given, in studies, and what happened' without prescribing anything.T-02Isomer half-life and washout tableThe measured pharmacokinetic asymmetry between enclomiphene and zuclomiphene, with a simple decay widget for enclomiphene only. The zuclomiphene side deliberately renders measured persistence data instead of a computed curve, because its terminal half-life could not be conventionally estimated.T-03Monitoring panel: what the trials measuredNo approved label directs enclomiphene monitoring. This panel assembles, lab by lab, what the clinical program actually measured, what moved, and which class schedules from approved alternatives are worth borrowing, with a symptoms row the regulators would insist on.

All guides

65 in-depth, individually cited guides.

Review-gated archive: the guides below are preserved for individual medical and source review. They are excluded from search indexing and AI citation files.

Evidence 20 guides

Enclomiphene and birth control: what men need to knowEnclomiphene isn't birth control. It can raise sperm production while TRT often suppresses it to zero. Here's the fertility evidence and the regulatory reality.Updated 2026-07-30Read guide →
Enclomiphene first month: what to expect week by weekEnclomiphene's first month: labs rise by week 3-4, side effects are usually mild, and fertility markers stay largely intact. Here's the real timeline.Updated 2026-07-30Read guide →
Enclomiphene FAQ: fertility, dosing, and legal statusStraight answers on enclomiphene: is it FDA-approved (no), does it preserve fertility, how it differs from clomiphene, dosing, side effects, and where it's legally sold.Updated 2026-07-30Read guide →
Enclomiphene myths vs facts: what the evidence really saysIs enclomiphene FDA-approved? Does it really preserve fertility? We separate marketing claims from the actual trial data and regulatory record.Updated 2026-07-30Read guide →
Enclomiphene pros and cons: the honest tradeoffsEnclomiphene raises testosterone and largely preserves fertility, but it's compounded, not FDA-approved, and lacks long-term outcome data. Here's the full picture.Updated 2026-07-30Read guide →
Enclomiphene rebound effect: what happens when you stopDoes testosterone crash after stopping enclomiphene? Here's what the mechanism, half-life, and available data actually say about rebound and withdrawal.Updated 2026-07-30Read guide →
Enclomiphene results timeline: what to expect week by weekMost men see labs shift by week 2 to 4 and symptoms improve by week 8 to 12 on enclomiphene. Here's the realistic timeline, backed by the actual trial data.Updated 2026-07-30Read guide →
Enclomiphene reviews: what actually works and what's hypeReal-world enclomiphene reviews, decoded: fertility preservation vs TRT, compounded status, side effects, and what buyers actually report after 3-6 months.Updated 2026-07-30Read guide →
Enclomiphene success rate: what the actual studies showTrials put testosterone normalization around 80-90% on enclomiphene, with LH, FSH and sperm parameters largely preserved. Here's the real evidence, dose by dose.Updated 2026-07-30Read guide →
How long until enclomiphene works? A realistic timelineMost men see testosterone rise within 2-4 weeks on enclomiphene, with symptoms improving by week 6-12. Here's what the trial data and bloodwork timing actually show.Updated 2026-07-30Read guide →
Natural alternatives to enclomiphene: what actually worksAshwagandha, D-aspartic acid, zinc, and weight loss can nudge testosterone a bit. None matches enclomiphene's LH-driven rise. Here's the real evidence.Updated 2026-07-30Read guide →
Enclomiphene: animal studies vs. the human evidenceRat and dog data helped build enclomiphene's case, but human trials with real numbers exist too. Here's what each actually shows and where the gaps remain.Updated 2026-07-27Read guide →
Enclomiphene before and after: what the evidence showsEnclomiphene before and after claims, checked against the actual trial data on testosterone, fertility, and testicular size. See what's proven vs. anecdote.Updated 2026-07-27Read guide →
Enclomiphene clinical trials: what the evidence really showsEnclomiphene never won FDA approval despite Phase 3 trials. Here's what the Androxal data, fertility studies, and compounding reality mean for you.Updated 2026-07-27Read guide →
Enclomiphene human studies: what the evidence actually showsEnclomiphene raised testosterone in men in trials of 200-900+ patients, but it was never FDA-approved. Here's what the human data really says.Updated 2026-07-27Read guide →
Enclomiphene in women: does it actually work?Enclomiphene isn't approved or studied for women's use. Here's what the ovulation-induction data on isomer-pure SERMs actually shows, and why clomiphene stays standard.Updated 2026-07-27Read guide →
Enclomiphene mechanism of action: how it raises testosteroneEnclomiphene blocks estrogen receptors in the hypothalamus, raising LH, FSH and testosterone while sparing sperm production. Here's the actual mechanism and evidence.Updated 2026-07-27Read guide →
Enclomiphene results: what the research actually showsEnclomiphene raises testosterone and LH/FSH in multiple trials while sparing sperm counts. Here's the real data, the gaps, and why it's still compounded, not FDA-approved.Updated 2026-07-27Read guide →
Is Enclomiphene FDA approved? The honest answerEnclomiphene is not FDA-approved as a standalone drug. It's dispensed as a compounded medication. Here's what that means for safety, sourcing, and fertility.Updated 2026-07-27Read guide →
What does Enclomiphene actually do?Enclomiphene connects men to compounded enclomiphene via licensed providers and pharmacies. Here's what it treats, what it doesn't, and the FDA status you should know.Updated 2026-07-27Read guide →

Safety 15 guides

Enclomiphene and alcohol: what actually happens if you mix themNo hard interaction study exists, but liver metabolism and hormone data give a real answer. Here's what's known about enclomiphene and alcohol together.Updated 2026-07-30Read guide →
Enclomiphene and antidepressants: what the interaction risk isSSRIs and SNRIs can already lower libido and testosterone effects. Here's what's known (and not known) about combining enclomiphene with antidepressants.Updated 2026-07-30Read guide →
Enclomiphene and pregnancy: fertility facts men need to knowEnclomiphene preserves sperm production and testicular size better than TRT, but it's not FDA-approved and doesn't guarantee conception. Here's the actual evidence.Updated 2026-07-30Read guide →
Enclomiphene common mistakes: what men get wrong on itMost enclomiphene mistakes come down to dosing, monitoring, or sourcing. Here are the errors that cost men results, money, or safety, and how to avoid them.Updated 2026-07-30Read guide →
Enclomiphene in older adults: what the evidence showsEnclomiphene in men over 50-65: how it compares to TRT for low T, what the trial data (age up to 60-65) actually covered, and open safety questions.Updated 2026-07-30Read guide →
Enclomiphene not working? 9 real reasons and what to checkTestosterone not moving on enclomiphene? Dosing, timing, compounding quality, and diagnosis errors are the usual culprits. Here's how to troubleshoot it.Updated 2026-07-30Read guide →
Enclomiphene overdose and toxicity: what the data saysNo enclomiphene lethal dose is established in humans. Studies used up to 25mg/day. Here's what overdose symptoms, risks, and toxicity data actually show.Updated 2026-07-30Read guide →
Enclomiphene withdrawal and stopping: what happens afterWhat to expect when you stop enclomiphene: hormone timelines, withdrawal symptoms, HPG axis recovery, and how it differs from coming off injectable TRT.Updated 2026-07-30Read guide →
Enclomiphene and drug testing: what athletes need to knowEnclomiphene is banned by WADA as a Section S4 hormone modulator, detectable in testing, and grounds for a suspension even without competing.Updated 2026-07-27Read guide →
Enclomiphene and blood work: what to test and whenEnclomiphene blood work guide: which labs to run before and during treatment, expected testosterone and LH/FSH changes, and how often to retest.Updated 2026-07-27Read guide →
Enclomiphene contraindications: who should not take itEnclomiphene is not for men with liver disease, active blood clots, hormone-sensitive cancers, or anyone trying to rule out primary testicular failure first.Updated 2026-07-27Read guide →
Enclomiphene drug interactions: what actually mattersEnclomiphene interacts with anticoagulants, other estrogen-modulating drugs, and liver-metabolized medications. Here's the real risk list, not a scare list.Updated 2026-07-27Read guide →
Enclomiphene long term side effects: what the data showsNo trial has followed enclomiphene past 6 months. Here's what the 3-6 month data, the failed Androxal program, and clomiphene research actually show.Updated 2026-07-27Read guide →
Enclomiphene side effects: what the evidence really showsEnclomiphene's most common side effects in trials: headache, nausea, and mood changes. See real trial data, fertility contrast with TRT, and who should avoid it.Updated 2026-07-27Read guide →
Is Enclomiphene safe? A regulatory and safety reviewEnclomiphene isn't FDA-approved; it's compounded. Here's what the safety data, fertility research, and pharmacy oversight actually show before you buy.Updated 2026-07-27Read guide →

Sourcing 12 guides

Enclomiphene compounded vs brand name: the buyer reality checkThere is no FDA-approved enclomiphene brand. Every legal source is a compounded prescription. Here's what that means for quality, cost, and safety.Updated 2026-07-30Read guide →
Enclomiphene online prescription requirements, explainedEnclomiphene isn't FDA-approved; every legal script is compounded and requires labs plus a licensed prescriber. Here's what that actually looks like in 2026.Updated 2026-07-30Read guide →
Enclomiphene telehealth options: what you're actually buyingEnclomiphene telehealth means a compounded prescription, not an FDA-approved drug. Here's what's legit, what costs $75-250/mo, and what to ask before you pay.Updated 2026-07-30Read guide →
Does enclomiphene need to be refrigerated? Storage guideMost compounded enclomiphene is stable at room temperature (68-77°F), but check your pharmacy label. Here's what USP storage rules actually require.Updated 2026-07-27Read guide →
Enclomiphene certificate of analysis, explainedWhat a COA on compounded enclomiphene should show, what USP <795> requires, and the questions to ask before you trust a purity number.Updated 2026-07-27Read guide →
Enclomiphene: compounding pharmacy vs research supplierEnclomiphene isn't FDA-approved solo, so every source is either a licensed compounding pharmacy or an unregulated research chemical seller. Here's the real difference.Updated 2026-07-27Read guide →
Enclomiphene cost and pricing: what you actually payEnclomiphene runs roughly $50-$150+ per month depending on dose and pharmacy. Here's the real breakdown, including compounding, telehealth, and labs.Updated 2026-07-27Read guide →
Enclomiphene legal status: is it FDA-approved or legal to buy?Enclomiphene is not FDA-approved as a standalone drug. What's sold is compounded. Here's what that means legally, medically, and for your prescription.Updated 2026-07-27Read guide →
Enclomiphene prescription requirements: what you actually needEnclomiphene isn't FDA-approved and is only legal with a valid prescription for a compounded product. Here's what that actually requires and why.Updated 2026-07-27Read guide →
Enclomiphene purity and testing: what buyers should verifyEnclomiphene isn't FDA-approved as a standalone drug, so purity depends on the compounding pharmacy. Here's what testing actually exists and what to ask for.Updated 2026-07-27Read guide →
Enclomiphene storage and shelf life explainedVials go in the fridge (36-46°F), most compounded enclomiphene holds potency 90 days to 6 months once mixed. Here's what pharmacy and USP guidance actually say.Updated 2026-07-27Read guide →
How to verify Enclomiphene quality before you buyNo FDA-approved enclomiphene product exists. Here's how to check a COA, verify the pharmacy's state license, and spot red flags before you buy.Updated 2026-07-27Read guide →

Dosing 10 guides

Enclomiphene for beginners: the complete starter guideNew to enclomiphene? Learn how it works, typical starting doses, fertility effects, and why it's compounded, not FDA-approved, before you start.Updated 2026-07-30Read guide →
Enclomiphene cycle length: how long should a run last?Most enclomiphene protocols run 8 to 16 weeks with bloodwork checkpoints. Here's what determines cycle length, when to retest, and why 'forever' isn't the plan.Updated 2026-07-27Read guide →
Enclomiphene dosage: how much, how often, and whyMost protocols use 12.5-25mg enclomiphene daily or every other day. Here's what the dose-ranging trials actually showed, and where the evidence stops.Updated 2026-07-27Read guide →
Enclomiphene dosage calculator: how doses actually workThere's no validated enclomiphene dosage calculator. Here's the real dosing range (6.25-25mg), how clinicians titrate it, and why bloodwork beats any formula.Updated 2026-07-27Read guide →
Enclomiphene half life: how long it stays in your systemEnclomiphene's half life runs roughly 10 hours to about 4 days depending on the study. Here's what that means for dosing frequency, blood tests, and washout time.Updated 2026-07-27Read guide →
Enclomiphene: how to inject, and why you probably don'tEnclomiphene is an oral SERM, not an injectable. Here's why the question comes up, how it's actually dosed, and where injections fit in TRT comparisons.Updated 2026-07-27Read guide →
Enclomiphene injection sites: the honest answer is none neededEnclomiphene is an oral SERM capsule, not an injectable. Here's why 'injection sites' is the wrong question, and what dosing actually looks like.Updated 2026-07-27Read guide →
Enclomiphene timeline: what to expect week by weekWhat actually happens on enclomiphene, week by week: labs at baseline, symptom shifts by week 3-4, T levels rechecked at 6-8 weeks. Full timeline inside.Updated 2026-07-27Read guide →
How long does enclomiphene take to work?Most men notice changes in libido and energy in 1-3 weeks, with testosterone rising on labs by week 4-6. Here's the real timeline and what affects it.Updated 2026-07-27Read guide →
How to reconstitute enclomiphene: the honest answerMost enclomiphene comes as a capsule, not a powder, so most men never reconstitute anything. Here's when reconstitution actually applies and how it's done.Updated 2026-07-27Read guide →

Comparisons 8 guides

Enclomiphene alternatives: TRT, clomiphene, hCG and SERMs comparedEnclomiphene alternatives include testosterone therapy, clomiphene, hCG, and other SERMs. See fertility effects, FDA status, and evidence for each option.Updated 2026-07-30Read guide →
Enclomiphene cost per month: what you'll actually payEnclomiphene runs about $75 to $250 a month from compounding pharmacies. Here's the real breakdown by source, why it's not FDA-approved, and where cost hides.Updated 2026-07-30Read guide →
Is enclomiphene worth it? An honest cost-benefit lookIs enclomiphene worth it versus TRT? Compare fertility preservation, cost ($100-250/mo), FDA status, and side effects before you decide.Updated 2026-07-30Read guide →
Enclomiphene vs clomiphene: what's the real differenceEnclomiphene is one of clomiphene's two isomers, not a new drug. Here's the pharmacology, the fertility angle, and the regulatory status, fact by fact.Updated 2026-07-27Read guide →
Enclomiphene vs hCG: which preserves fertility better on TRTEnclomiphene raises LH and FSH at the brain; hCG mimics LH at the testicle. Compare mechanism, fertility data, cost, and side effects before you choose.Updated 2026-07-27Read guide →
Enclomiphene vs tamoxifen: which SERM actually fits your goalEnclomiphene isolates the testosterone-raising isomer; tamoxifen is FDA-approved but built for breast cancer. Neither is FDA-approved for low T. Here's the real comparison.Updated 2026-07-27Read guide →
Enclomiphene vs testosterone injections: the real tradeoffsEnclomiphene raises T while likely preserving fertility; TRT injections shut down sperm production. Compare mechanism, cost, and evidence here.Updated 2026-07-27Read guide →
Enclomiphene vs TRT: fertility, testosterone, and the factsEnclomiphene raises testosterone via the hypothalamus and tends to preserve fertility; TRT shuts down sperm production. Neither Androxal nor generic enclomiphene is FDA-approved.Updated 2026-07-27Read guide →

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